Manchester United qualified for their first ever Europa League Final following a 2-1 aggregate win over Celta de Vigo in the Semi-Finals, but will be without Ivorian defender Eric Bailly against Ajax on May 24.
Bailly was shown a straight red card for putting his hand in the face of former Manchester City man John Guidetti in the second leg at Old Trafford.
The loss of Bailly comes at an awkward time for United as they desperately search for Champions League qualification, and he joins Zlatan Ibrahimovic, Marcos Rojo and Luke Shaw on the omissions list.
Jose Mourinho has better news coming from the return of Chris Smalling, who appeared as a late substitute in the dying moments of the Semi-Final with Celta de Vigo.
Phil Jones is also back in contention following a lengthy layoff with a toe injury, while Daley Blind is another backup option in defence.
The Red Devils will come up against a youthful Ajax side in the Final, who progressed after a 5-4 aggregate victory over Olympique Lyonnais.